intermediate work · Validated DNAm/telomere kit or accredited lab, Los Angeles, CA
Epigenetic (DNA-methylation) biological-age estimate — Los Angeles.
Fund it for $800. Proof lands onchain when it's done.
$800 proposed
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What the work involvesLos Angeles, CA is home to UCLA, where Steve Horvath built the original multi-tissue epigenetic clock: Horvath S. 'DNA methylation age of human tissues and cell types.' Genome Biol. 2013;14(10):R115 -- a single-author landmark built from 353 CpG sites across 8,000 samples spanning 82 datasets and 51 healthy tissues and cell types, achieving a median age-prediction error of 3.6 years and r=0.96 correlation with chronological age. This library's own GrimAge tile already carries a Framingham connection for the newer, mortality-focused clock from the same lab -- the original 2013 clock is a distinct, earlier UCLA contribution, offered where the field itself began.
How this work is done
A documented method, so this packet comes out the same whoever does it.
Bring
- validated DNAm/telomere test kit or accredited lab
- chain-of-custody / mailer
- prior result for trend if available
Steps
- 1. Collect the sample per the validated kit (usually a blood spot or saliva) or arrange a lab draw; follow handling exactly.
- 2. Record the specific clock/method used (clocks are not interchangeable).
- 3. Capture the reported biological age (and/or telomere length) with the method's reference framing.
- 4. Compute the biological-vs-chronological age gap.
- 5. Frame explicitly as a research-grade longitudinal trend; attach the report and sign it. Make no clinical decision from a single value.
What counts as done
- DNAm biological age (and/or telomere length) from a validated method, with the specific clock named
- Biological-vs-chronological age gap computed
- Explicit framing as a research-grade longitudinal trend, not a clinical diagnosis
Proof is measured against these, not judged by taste.
What is promised, and what is not.
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