Anyone can start here · Telehealth / Philadelphia, PA (compute over an existing lipid panel)
TG/HDL-C ratio — free insulin-resistance signal from an existing lipid panel — Philadelphia, PA.
Fund it for $80. Proof lands onchain when it's done.
$80 proposed
Not funded yet. Settles as earned credit, $80 proposed.
- ProofTG (mg/dL) and HDL-C (mg/dL) from an accredited-lab lipid panel already on file + the computed ratio + the population-appropriate interpretation (or explicit non-applicability) + routing to the insulin_resistance HOMA-IR standard as the reliable alternative
- Open until2027-03-02
- Levelentry
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What the work involvesPhiladelphia, PA is the headquarters of the American College of Physicians (ACP) -- founded 1915, 162,000+ members, the largest medical-specialty organization in the US -- which publishes Annals of Internal Medicine, the exact journal this standard's foundational citation (McLaughlin, Abbasi, Cheal, Chu, Lamendola, Reaven. Ann Intern Med. 2003;139(10):802-809) appeared in, confirmed via WebFetch to Wikipedia. No honesty-limit caveat needed: the ACP is the direct publisher of the citation's own journal. Distinct from the existing Jackson tile, which is built on the Jackson Heart Study's own cohort finding about this ratio's population limit rather than the origin citation's publishing society. This ratio is a free derived number from an existing lipid panel, computed where the journal publishing its original population threshold is headquartered.
How this work is done
A documented method, so this packet comes out the same whoever does it.
Bring
- A recent accredited-lab lipid panel report already on file (TG and HDL-C values)
- A calculator
- The person's self-identified race/ethnicity, since the interpretation band depends on it
Steps
- 1. Locate a recent (ideally <=6 months old) accredited-lab lipid panel already on file; record the TG (mg/dL) and HDL-C (mg/dL) values with the draw date.
- 2. Compute TG/HDL-C = TG (mg/dL) / HDL-C (mg/dL); show the arithmetic in the record.
- 3. Ask the person's self-identified race/ethnicity ONLY to select the correct interpretation band — never to make any other inference.
- 4. For a general/white-cohort population: read >=3.0 as the McLaughlin 2003 insulin-resistance-associated threshold, flagging only.
- 5. For an African-American woman: state explicitly that the ratio is NOT interpretable for insulin resistance per Sumner et al. 2010 (Jackson Heart Study) -- record 'not applicable, do not use to rule out insulin resistance' rather than any numeric band.
- 6. For an African-American man: use the Sumner 2010 adjusted threshold of 2.5 (not the general 2.0/3.0 conventions), flagging only.
- 7. Regardless of band, name the insulin_resistance (fasting insulin + HOMA-IR) standard as the reliable next step if the person wants a direct, population-neutral measurement rather than this free derived signal alone; sign the record.
What counts as done
- TG and HDL-C values (mg/dL) transcribed from an existing accredited-lab lipid panel report, dated
- TG/HDL-C ratio computed and shown with the arithmetic
- Interpretation banded per the population-appropriate evidence: general/white-cohort threshold >=3.0 (McLaughlin 2003); African-American women — ratio explicitly NOT interpretable, stated as such, never used to reassure; African-American men — threshold 2.5, not 2.0 (Sumner 2010)
- The insulin_resistance (fasting insulin + HOMA-IR) standard named as the reliable, population-neutral alternative when this ratio's population limit applies or the result is ambiguous
Proof is measured against these, not judged by taste.
What is promised, and what is not.
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